Bronchogenic Carcinoma causes, pathology, classification and spread

Bronchogenic Carcinoma is the most common malignancy in males, it accounts for 32% of all cancer deaths in men, 85% of patients die within 5 years.. The risk is increased 40 times fold for man smoking two packs /d. for 20 years -Causes and incidence of Bronchogenic carcinoma-Methods of Spread of Bronchogenic carcinoma

Bronchogenic Carcinoma is the most common malignancy in males, it accounts for 32% of all cancer deaths in men, 85% of patients die within 5 years.

Causes and incidence of Bronchogenic carcinoma

 (no definite aetiology)
• Male > female
• Peak incidence occurs between ages 55 and 65 years.
• Predisposing factors:
• The major cause is tobacco use particularly cigarette smoking
• 3,4 benzpyrine is the carcinogenic substance especially if combined with asbestos.
• Air pollution (coal combustion, cadmium and radon).
• Occupation inhaled substances e.g asbestos, nickel and arsenic.
• Radiation e.g atomic bomb survivors, uranium miners.
• Genetic mechanism e.g dominant oncogenes and loss of tumour suppressor genes.

 The risk is increased 40 times fold for man smoking two packs /d. for 20 years .

Pathology

1- Central or hilar type in a main bronchus, it invades the mediastinum early
2- Peripheral in small bronchus, it invades pleura early
3- Pancoast tumour, it is apical and invades the thoracic inelt early.
Naked eye appearance : Fungating mass - Malignant ulcer - Infiltrative type
Microscopic:
WHO classification
WHO-classification-of-Bronchogenic-Carcinoma


Methods of Spread of  Bronchogenic carcinoma

Direct                   : lung, pleura, mediastinum, brachial plexus, sympathetic chain and phrenic nerve.

Lymphatic spread  :  - Hilar & mediastinum, then cervical L.N.
                                  -Retrograde lymphatic ==> (lymphangitis carcinomatosa) ==> cor pulmonale
Haematogenous    :   Bones, liver, brain

Bronchoalveolar cell carcinoma (Bronchiolar carcinoma) arising in the terminal bronchioloalveolar regions accounts for 1-2% of lung tumors.
 It may be a peripheral solitary nodule or diffuse nodular lesion. It occurs in men and women equally and
usually not associated with smoking.
It may be associated with expectoration of a large volumes of mucoid sputum.
Important articles to read : 
• Manifestations of Bronchogenic carcinoma (clinical picture)

COMMENTS

BLOGGER
Name

andrology,2,Cardiology,10,Differential-diagnosis,5,E.N.T,31,General Surgery,4,General-Health,6,GIT,19,Gynecology,1,Hepatology,8,Internal-medicine,1,Microbiology,3,Orthopedics,1,Psychiatry,3,Respiratory-diseases,59,Rheumatology,50,STDs,3,Symptomatology,9,Urology,36,
ltr
item
Med2Date: Bronchogenic Carcinoma causes, pathology, classification and spread
Bronchogenic Carcinoma causes, pathology, classification and spread
Bronchogenic Carcinoma is the most common malignancy in males, it accounts for 32% of all cancer deaths in men, 85% of patients die within 5 years.. The risk is increased 40 times fold for man smoking two packs /d. for 20 years -Causes and incidence of Bronchogenic carcinoma-Methods of Spread of Bronchogenic carcinoma
http://4.bp.blogspot.com/-YbvRwEGYAJ8/UeHNyFw9spI/AAAAAAAAETs/HAL9KfMAxIU/s640/Bronchogenic-Carcinoma.png
http://4.bp.blogspot.com/-YbvRwEGYAJ8/UeHNyFw9spI/AAAAAAAAETs/HAL9KfMAxIU/s72-c/Bronchogenic-Carcinoma.png
Med2Date
http://www.med2date.com/2013/07/bronchogenic-carcinoma-causes-pathology.html
http://www.med2date.com/
http://www.med2date.com/
http://www.med2date.com/2013/07/bronchogenic-carcinoma-causes-pathology.html
true
1129835733813637495
UTF-8
Loaded All Posts Not found any posts VIEW ALL Readmore Reply Cancel reply Delete By Home PAGES POSTS View All RECOMMENDED FOR YOU LABEL ARCHIVE SEARCH ALL POSTS Not found any post match with your request Back Home Sunday Monday Tuesday Wednesday Thursday Friday Saturday Sun Mon Tue Wed Thu Fri Sat January February March April May June July August September October November December Jan Feb Mar Apr May Jun Jul Aug Sep Oct Nov Dec just now 1 minute ago $$1$$ minutes ago 1 hour ago $$1$$ hours ago Yesterday $$1$$ days ago $$1$$ weeks ago more than 5 weeks ago Followers Follow THIS CONTENT IS PREMIUM Please share to unlock Copy All Code Select All Code All codes were copied to your clipboard Can not copy the codes / texts, please press [CTRL]+[C] (or CMD+C with Mac) to copy