Mixed Connective tissue disease features, diagnosis and treatment

Mixed Connective tissue disease MCTD 
• This syndrome involving mixed features of :-
- Myositis.
 - SLE.
- Scleroderma.
Clinical picture
- It is of gradual onset. - Renal affection is rare.
Features (according to the frequency)
1- Arthritis or arthralgia.
2- Raynaud's phenomenon.
3- Oesophageal dysmotility.
4- Lymphadenopathy.

5- Serositis.
6- Myositis.
7- Skin rash.
8- Fever.
9- Renal disorder.
Investigations
 • ANA +ve.
• Positive anti-ribonucleoprotein (RNP) antibodies.
Treatment 
Good response to steroid.

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