Mixed Connective tissue disease MCTD
• This syndrome involving mixed features of :-- Myositis.
- SLE.
- Scleroderma.
Clinical picture
- It is of gradual onset. - Renal affection is rare.
Features (according to the frequency)
1- Arthritis or arthralgia.
2- Raynaud's phenomenon.
3- Oesophageal dysmotility.
4- Lymphadenopathy.
5- Serositis.
6- Myositis.
7- Skin rash.
8- Fever.
9- Renal disorder.
Investigations
• ANA +ve.
• Positive anti-ribonucleoprotein (RNP) antibodies.
Treatment
Good response to steroid.