Diuretics: Thiazides and Furosemide in treatment of Hypertension

This article to discuss the use of Diureticin treatment of cases of Hypertension

This article to discuss the use of Diureticin treatment  of cases of Hypertension

Value : Na excretion --> decrease reactivity of blood vessels to catecholamines with reduction of blood and extracellular fluid.

Thiazides:

Value: Diuresis, vasodilatation - can be tolerated for long time.

Dose: Dihydrochlorothiazide 12.5 mg/d up to 50 mg/d.

N.B
Indapamide (Natrilix) is related to thiazides 2.S mg tablet/d. It has little effect on potassium, glucose, uric acid excretion. It has a vasodilator effect as it blocks calcium influx in blood vessels .

Furosemide

It is not routinely used in stable cases of Hypertension
- It is indicated in cases of :

Spironolactone 

- It is an Aldosterone -antagonist .
- Used in Conn's syndrome ( Primary hyperaldosteronism) .
- Dose : 400 mg/day .

Amiloride or spironolactone are not effective when used alone, with the exception of spironolactone in primary hyperaldosteronism.

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Med2Date: Diuretics: Thiazides and Furosemide in treatment of Hypertension
Diuretics: Thiazides and Furosemide in treatment of Hypertension
This article to discuss the use of Diureticin treatment of cases of Hypertension
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