Diuretics: Thiazides and Furosemide in treatment of Hypertension

This article to discuss the use of Diureticin treatment  of cases of Hypertension

Value : Na excretion --> decrease reactivity of blood vessels to catecholamines with reduction of blood and extracellular fluid.

Thiazides:

Value: Diuresis, vasodilatation - can be tolerated for long time.

Dose: Dihydrochlorothiazide 12.5 mg/d up to 50 mg/d.

N.B
Indapamide (Natrilix) is related to thiazides 2.S mg tablet/d. It has little effect on potassium, glucose, uric acid excretion. It has a vasodilator effect as it blocks calcium influx in blood vessels .

Furosemide

It is not routinely used in stable cases of Hypertension
- It is indicated in cases of :

Spironolactone 

- It is an Aldosterone -antagonist .
- Used in Conn's syndrome ( Primary hyperaldosteronism) .
- Dose : 400 mg/day .

Amiloride or spironolactone are not effective when used alone, with the exception of spironolactone in primary hyperaldosteronism.

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