Rheumatoid factor R.F detection and significance

It is an IgM Ab (occasionally IgG, IgA or IgE) which reacts with Fc portion of human IgG, this occurs usually in patients with rheumatoid disease (70-80% of cases), but is not diagnostic. • It exists as an (Rh.F. - Ig.G - C) complex in synovial membrane. Methods of detection Conditions in which Rh. F is +ve

What is Rheumatoid factor (R.F) ?

• It is an IgM Ab (occasionally IgG, IgA or IgE) which reacts with Fc portion of human IgG, this occurs usually in patients with rheumatoid
disease (70-80% of cases), but is not diagnostic.
• It exists as an (Rh.F. - Ig.G - C) complex in synovial membrane.
So, complement is lowered in synovial fluid and not in the serum.

Methods of detection


1- Latex method (agglutination test)

Ab (Rh. F. in the serum) +
Ag (latex coated with Ig G)

2- Rose waaler test. (agglutination test)
Ab (Rh. F. in the serum) +
Ag (sheep's RBCs coated witl1 anti-erythrocyte antibodies)

Latex is more sensitive, but Rose Waaler is more specific.

Conditions in which Rh. F is +ve

Autoimmune rheumatic diseases .
 - Rheumatoid arthritis (70 % - 80 %).
 - SLE (15-35 %)
 - Polymyositis, dermatomyositis (5-10 %).
 - Mixed connective tissue disease (50-60%).
 - Sjogren's disease (90 %).
 - Scleroderma (30 %).

Infections
 - T. B.           - Infective endocarditis.
 - Syphilis       - Kala - azar
 - HCV - HIV

Normal population
Especially elderly and relatives of patients with rheumatoid arthritis.

Miscellaneous .
Autoimmune hepatitis.        - Fibrosing alveolitis.
Sarcoidosis.                       - Waldenstroms macroglobulmamia.
Chronic liver disease.         - Cryoglobulinemia.

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Med2Date: Rheumatoid factor R.F detection and significance
Rheumatoid factor R.F detection and significance
It is an IgM Ab (occasionally IgG, IgA or IgE) which reacts with Fc portion of human IgG, this occurs usually in patients with rheumatoid disease (70-80% of cases), but is not diagnostic. • It exists as an (Rh.F. - Ig.G - C) complex in synovial membrane. Methods of detection Conditions in which Rh. F is +ve
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