Manifestations and Features of chronic Liver cell failure

Here are the manifestations of chronic liver failure ,, Also known as Hepatocellular failure ( HCC) , which is caused by chronic degenerative liver diseases e.g Liver Cirrhosis .

1. General failure of health .
i.e Anorexia , loss of weight , easy fatigue , ......

2. Low grade Fever  : due to failure of the lever to clear bacteria coming from the colon .

3. Fetor hepaticus : this is fecal smell of mouth due to lack of detoxification of Mercaptans absorbed from the colon ,, it occurs also with porto-systemic shunts .

4. Hepatocellular Jaundice : due to diminished uptake & excretion of bilirubin .

5. Ascites and Edema : 

Edema of  lower limbs usually follows acsites .
Ascites usually develops grudually ,, but it may develop Acutely in cases of haematemesis , melena , infection as SBP hypotension ( hypovolemia) , portal vein thrombosis and malignancy development .

6. Skin manifestations :
a- Palmar erythema : erythema opposite the heads of metacarpal bones , thenar & hypothenar eminences with central palmar pallor .
b. Spider naevi  ,, each of them is a dilated arteriole with radiating capillaries ,, when compressing the central arteriole it causes blanching of  capillaries .Spider naevi occur on the face , neck , upper limb & upper part of chest .
c. White nails .

7. Endocrinal changes : whose cause is not yet defined .
A . Male changes 
Gynaecomastia , female distribution of suprapubic hair , decreased libido , impotence and testicular atrophy .
B. Female changes 
Amenorrhoea , Sterility &  decreased libido .

8. Cardio-Vascular manifestations :
a. Hyperkinetic circulation >> due to V.D materials esp. Nitric Oxide .
b. Cyanosis and Clubbing  (Hepato-Pulmonary syndrome ) .

9. Hematological manifestations 
Bleeding tendency , Anemia and Pancytopenia .

10. Hepatic Encephalopathy 
it is a neuropsychiatric syndrome that may complicate severe liver disease and/or extensive portosystemic shunting .

11. Hepato-Renal syndrome :
it is Acute renal failure with normal renal histology occurs in Child C liver cirrhosis .
Manifestations and Features of chronic Liver cell failure
Dr.Tamer Mobarak


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    Unknown7:52 AM

    I really appreciate this blog for bringing up the liver problem symptoms.I believe this blog will help many people out there who are suffering from liver disease. Keep this up and be healthy to all who gonna read this!

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