• It is not a glomerulonephritis, but it is considered to be glomerulopathy.
• It presents with nephrotic syndrome, then deterioration of kidney function, eventually leading to chronic renal failure.
Causes :
1. Rheumatoid disease.
2. Suppurative lung syndrome .
3. Familial Mediterranean Fever (FMF) :
Polyserositis with recurrent abdominal pain + rebound tenderness.
- Fever (recurrent).
- Nephrotic syndrome usually develops late.
4. Multiple myeloma - non Hodgkin's lymphoma.
Amyloid deposition in kidney may be consisting of immunoglobulin light chains (AL-amyloid) which occurs in cases of multiple myeloma, Waldenstrom's disease, non Hodgkin's lymphoma or in primary amyloidosis.
• Amyloid A is found in long standing inflammatory conditions e.g.suppurative lung diseases, rheumatoid arthritis and FMF.
• Amyloidosis kidney also leads to renal tubular acidosis and nephrogenic diabetes insipidus.
• Steroids and melphalan may be helpful in primary amyloidosis.
• Colchicine in F.M.F. decreases the incidence of amyloidosis .
• Treatment of nephrotic $ and chronic renal failure.
• It presents with nephrotic syndrome, then deterioration of kidney function, eventually leading to chronic renal failure.
Causes :
1. Rheumatoid disease.
2. Suppurative lung syndrome .
3. Familial Mediterranean Fever (FMF) :
Polyserositis with recurrent abdominal pain + rebound tenderness.
- Fever (recurrent).
- Nephrotic syndrome usually develops late.
4. Multiple myeloma - non Hodgkin's lymphoma.
Amyloid deposition in kidney may be consisting of immunoglobulin light chains (AL-amyloid) which occurs in cases of multiple myeloma, Waldenstrom's disease, non Hodgkin's lymphoma or in primary amyloidosis.
• Amyloid A is found in long standing inflammatory conditions e.g.suppurative lung diseases, rheumatoid arthritis and FMF.
Clinical Picture:
• C/P of the Cause + Nephrotic syndrome .• Amyloidosis kidney also leads to renal tubular acidosis and nephrogenic diabetes insipidus.
Diagnosis:
• Biopsy and staining by Congo red, this gives pink color & shows green birefringence by polarized microscope.Treatment:
• Treatment of the cause to prevent further amyloid deposition.• Steroids and melphalan may be helpful in primary amyloidosis.
• Colchicine in F.M.F. decreases the incidence of amyloidosis .
• Treatment of nephrotic $ and chronic renal failure.