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Behcet's disease def., manifestations, diagnostic criteria and treatment

What is Behcet's disease ? (syndrome)• It is a systemic vasculitis of unknown etiology
- Viral.!? - Autoimmune.!?

• Diagnostic criteria of Behcet's disease ?

- Recurrent oral ulcers, at least three times in a 12 month period.
Plus two of:
- Uveitis or retinal vasculitis
- Skin lesions e.g erythema nodosum.
- Recurrent genital ulcers.
- Positive pathergy test
Behcet's-disease-syndrome

Oligoarthritis, thrombophlebitis and neurobehcet (multiple sclerosis like) may also occur.

Treatment of Behcet's disease ?

• Oral ulcers can be treated by topical steroids.
• Colchicine is effective for erythema nodosum and arthralgia.
• Systemic steroids in combination with other immunosuppressive drugs for systemic manifestations e.g ocular or neurological disease.

The pathergy test or reaction is highly specific to Behcet's disease .
Skin inflammatory reactivity to any scratches or intradermal saline injection,, this leads to papule or pustule formation within 24-48 hours .
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Tamer Mobarak

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