This article to discuss the use of Diureticin treatment of cases of Hypertension
Value : Na excretion --> decrease reactivity of blood vessels to catecholamines with reduction of blood and extracellular fluid.
Thiazides:
Value: Diuresis, vasodilatation - can be tolerated for long time.
Dose: Dihydrochlorothiazide 12.5 mg/d up to 50 mg/d.
N.B
Indapamide (Natrilix) is related to thiazides 2.S mg tablet/d. It has little effect on potassium, glucose, uric acid excretion. It has a vasodilator effect as it blocks calcium influx in blood vessels .
- It is indicated in cases of :
Dose: Dihydrochlorothiazide 12.5 mg/d up to 50 mg/d.
N.B
Indapamide (Natrilix) is related to thiazides 2.S mg tablet/d. It has little effect on potassium, glucose, uric acid excretion. It has a vasodilator effect as it blocks calcium influx in blood vessels .
Furosemide
It is not routinely used in stable cases of Hypertension- It is indicated in cases of :
- Emergency e.g Hypertensive encephalopathy .
- Salt and water retention e.g Nephritic syndrome .
- GFR < 25 ml/min .
Spironolactone
- It is an Aldosterone -antagonist .
- Used in Conn's syndrome ( Primary hyperaldosteronism) .
- Dose : 400 mg/day .
Amiloride or spironolactone are not effective when used alone, with the exception of spironolactone in primary hyperaldosteronism.