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Non-Alcoholic fatty liver disease (NAFLD)

Here we will discuss the definition , causes , diagnosis and treatment of Non-Alcoholic fatty liver disease .

Definition

 Spectrum of liver disease caused by excees fat in the liver 

 **  Steatosis—> Non-Alcoholic Steato-Hepatitis —> Cirrhosis .

What is meant by Steatosis ?
 - Steatosis means fat exceeding 5% of the liver Wei ght.
 -  Steatohepatitis :  inflammation associated with steatosis.

Causes

  • obesity
  • Diabetes mellitus 
  • HyperLipidaemia
  • Malnutrition
  • Drugs eg. contraceptives & methotrexate.

Diagnosis

-Hepatomegaly which may be tender.
- Elevated transferases in NASH. 
- Bright liver by ultrasonography.

- Liver biopsy shows excess fat.

Treatment

1. Treatment of the cause.
2. Avoid fat & diminish carbohydrate in diet.
3. Excess fruits & fresh vegetables.
4. Regular physical exercise.
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Tamer Mobarak

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