Non-Alcoholic fatty liver disease (NAFLD)

Dr.Tamer Mobarak

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Here we will discuss the definition , causes , diagnosis and treatment of Non-Alcoholic fatty liver disease .

Definition

Spectrum of liver disease caused by excees fat in the liver

** Steatosis—> Non-Alcoholic Steato-Hepatitis —> Cirrhosis .

What is meant by Steatosis ?

- Steatosis means fat exceeding 5% of the liver Wei ght.

- Steatohepatitis : inflammation associated with steatosis.

Causes

obesity
Diabetes mellitus
HyperLipidaemia
Malnutrition
Drugs eg. contraceptives & methotrexate.

Diagnosis

-Hepatomegaly which may be tender.

- Elevated transferases in NASH.

- Bright liver by ultrasonography.

- Liver biopsy shows excess fat.

Treatment

1. Treatment of the cause.

2. Avoid fat & diminish carbohydrate in diet.

3. Excess fruits & fresh vegetables.

4. Regular physical exercise.

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